DIFFERENTIAL ELIMINATION OF CIRCADIAN AND ULTRADIAN RHYTHMICITY BY HYPOTHALAMIC-LESIONS IN THE COMMON VOLE, MICROTUS-ARVALIS

被引：91

作者：

GERKEMA, MP

GROOS, GA

DAAN, S

机构：

[1] Zoological Laboratory, Groningen University, Haren

[2] Max-Planck-Institut für Verhaltensphysiologie, Andechs

来源：

JOURNAL OF BIOLOGICAL RHYTHMS | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1177/074873049000500201

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Effects of hypothalamic lesions on the ultradian and circadian organization of wheel running and feeding were studied in the common vole, Microtus arvalis. Circadian organization broke down within 30 days in continuous darkness in 24% of intact voles (n = 135). Ultradian rhythmicity of feeding (period 2-3 hr) persisted in constant conditions in all intact voles. Following lesions of the suprachiasmatic nuclei (SCN), circadian rhythmicity disappeared when lesions were complete (n = 8) or more extensive than 25% of the total SCN volume (n = 5). Absence of circadian rhythmicity was also found in animals with substantial lesions in the diencephalic paraventricular area (PVA) and in the retrochiasmatic area (RCA) and/or adjacent arcuate nucleus (Arc). Complete loss of ultradian and circadian organization occurred in eight voles with damage to the RCA and/or Arc. In three of these, the SCN was intact. The SCN is a likely candidate for a circadian pacemaker in voles (as in other rodents), while the loss of circadian rhythmicity following PVA and RCA/Arc lesions may be due to destruction of efferent pathways from the SCN. The RCA/Arc area is apparently necessary for the expression of ultradian rhythms. The intact SCN is neither necessary nor sufficient for the generation of ultradian rhythmicity. © 1990, Sage Publications. All rights reserved.

引用

页码：81 / 95

页数：15

共 47 条

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