LEUKEMIA OF NOVEL GASTROINTESTINAL LYMPHOCYTE-T POPULATION INFECTED WITH HTLV-I

被引：22

作者：

HATTORI, T ^{[1
]}

ASOU, N ^{[1
]}

SUZUSHIMA, H ^{[1
]}

TAKATSUKI, K ^{[1
]}

TANAKA, K ^{[1
]}

NAITO, K ^{[1
]}

NATORI, H ^{[1
]}

OIZUMI, K ^{[1
]}

机构：

[1] KURUME UNIV, SCH MED, DEPT INTERNAL MED 1, KURUME, FUKUOKA 830, JAPAN

来源：

LANCET | 1991年 / 337卷 / 8733期

关键词：

D O I：

10.1016/0140-6736(91)90737-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR alpha-beta products. Southern blotting confirmed monoclonal integration of HTLV-1. A novel T-cell subset of double-negative TCR alpha-beta cells in the gastrointestinal tract in adult man may be a target for HTLV-1 infection.

引用

页码：76 / 77

页数：2

共 9 条

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