ELECTROPHILIC CATALYSIS CAN EXPLAIN THE UNEXPECTED ACIDITY OF CARBON ACIDS IN ENZYME-CATALYZED REACTIONS

被引:160
作者
GERLT, JA
KOZARICH, JW
KENYON, GL
GASSMAN, PG
机构
[1] UNIV CALIF SAN FRANCISCO,SCH PHARM,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[2] UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455
关键词
D O I
10.1021/ja00025a039
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:9667 / 9669
页数:3
相关论文
共 50 条
[1]   EVOLUTION OF ENZYME FUNCTION AND DEVELOPMENT OF CATALYTIC EFFICIENCY [J].
ALBERY, WJ ;
KNOWLES, JR .
BIOCHEMISTRY, 1976, 15 (25) :5631-5640
[2]   ENERGETICS AND MECHANISM OF PROLINE RACEMASE [J].
ALBERY, WJ ;
KNOWLES, JR .
BIOCHEMISTRY, 1986, 25 (09) :2572-2577
[3]   MUTATION OF ESSENTIAL CATALYTIC RESIDUES IN PIG CITRATE SYNTHASE [J].
ALTER, GM ;
CASAZZA, JP ;
WANG, Z ;
NEMETH, P ;
SRERE, PA ;
EVANS, CT .
BIOCHEMISTRY, 1990, 29 (33) :7557-7563
[4]   PHOSPHONATE ANALOG SUBSTRATES FOR ENOLASE [J].
ANDERSON, VE ;
CLELAND, WW .
BIOCHEMISTRY, 1990, 29 (46) :10498-10503
[5]  
BAGNO A, 1987, B SOC CHIM FR, P563
[6]  
BENKOVIC SJ, 1966, BIOORGANIC REACTION, pCH3
[7]   HOW CAN A CATALYTIC LESION BE OFFSET - THE ENERGETICS OF 2 PSEUDOREVERTANT TRIOSEPHOSPHATE ISOMERASES [J].
BLACKLOW, SC ;
KNOWLES, JR .
BIOCHEMISTRY, 1990, 29 (17) :4099-4108
[8]  
CHARI RVJ, 1981, J BIOL CHEM, V256, P9785
[9]   ENOLS AND OTHER REACTIVE SPECIES [J].
CHIANG, Y ;
KRESGE, AJ .
SCIENCE, 1991, 253 (5018) :395-400
[10]   THE ENOL OF MANDELIC-ACID, DETECTION, ACIDITY IN AQUEOUS-SOLUTION, AND ESTIMATION OF THE KETO-ENOL EQUILIBRIUM-CONSTANT AND CARBON ACIDITY OF MANDELIC-ACID [J].
CHIANG, Y ;
KRESGE, AJ ;
PRUSZYNSKI, P ;
SCHEPP, NP ;
WIRZ, J .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1990, 29 (07) :792-794