CHOP VERSUS CHLORAMBUCIL + PREDNISOLONE IN CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：31

作者：

HANSEN, MM

ANDERSEN, E

BIRGENS, H

CHRISTENSEN, BE

CHRISTENSEN, TG

GEISLER, C

MELDGAARD, K

PEDERSEN, D

机构：

[1] Rigshospitalet, Med.-Hematol. Dept. L, Copenhagen

[2] Viborg Hospital, Med. Dept. L

[3] Gentofte Hospital, Med.-Hematol. Dept. C

[4] Odense Hospital, Hematol. Dept. R

[5] Hvidovre Hospital, Med.-Hematol. Dept. L

[6] Aarhus County Hospital, Med.-Hematol. Dept. B

[7] Aarhus Municipal Hospital, The Radium Centre

来源：

LEUKEMIA & LYMPHOMA | 1991年 / 5卷

关键词：

CLL; CHEMOTHERAPY; CHOP; CHLORAMBUCIL AND PREDNISONE;

D O I：

10.3109/10428199109103387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One hundred and fifty-seven previously untreated stage B or C B-CLL patients were randomized to treatment with either chlorambucil + prednisolone (CLBP) 5 days every 4 weeks or CHOP every 4 weeks. Significantly more patients achieved complete remission on CHOP, but duration of response and survival were equal in the two regimens. Non-responders on CLBP were switched to CHOP, so that finally most patients received nearly the same amount and quality of treatment, which possibly explains the lack of difference in survival. However, compared to previous studies, the study-designed intensive chemotherapy seems to prolong survival for patients with advanced disease, especially those in stage C. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：97 / 100

页数：4

共 7 条

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