FUNCTIONAL EVIDENCE THAT ACETYLCHOLINE-RELEASE FROM AUERBACH PLEXUS OF GUINEA-PIG ILEUM IS MODULATED BY ALPHA-2A-ADRENOCEPTOR SUBTYPE

被引:28
作者
BLANDIZZI, C
DODA, M
TARKOVACS, G
DELTACCA, M
VIZI, ES
机构
[1] HUNGARIAN ACAD SCI,INST EXPTL MED,POB 67,H-1450 BUDAPEST,HUNGARY
[2] UNIV PISA,INST MED PHARMACOL,I-56126 PISA,ITALY
关键词
ALPHA-2A-ADRENOCEPTORS; ALPHA-2B-ADRENOCEPTORS; OXYMETAZOLINE; WB-4101; PRAZOSIN; ACETYLCHOLINE RELEASE; ILEUM (GUINEA-PIG);
D O I
10.1016/0014-2999(91)90916-E
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of alpha-2-adrenoceptor ligands on electrically stimulated [H-3]acetylcholine release from longitudinal muscle strips of guinea-pig ileum were examined. Xylazine or oxymetazoline reduced the release of [H-3]acetylcholine in a concentration-dependent manner, both these actions being antagonized by idazoxan, CH 38083, or WB 4101. Prazosin, considered as an alpha-2B-adrenoceptor antagonist, failed to modify the inhibitory effects of xylazine or oxymetazoline. It is concluded that the alpha-2-adrenoceptors involved in the modulation of acetylcholine release from cholinergic axon terminals of guinea-pig ileum are of the alpha-2A subtype.
引用
收藏
页码:311 / 313
页数:3
相关论文
共 10 条