RELATION OF PHASIC CORONARY FLOW VELOCITY PROFILE TO CLINICAL AND HEMODYNAMIC CHARACTERISTICS OF PATIENTS WITH AORTIC-VALVE DISEASE

Background. Our objective was to assess phasic coronary blood flow and velocity characteristics of the proximal portion of the left anterior descending artery and to evaluate their relation to the clinical and hemodynamic manifestations in patients with aortic valve disease. Methods and Results. We examined 26 patients with chronic aortic regurgitation (AR), 12 patients with predominant aortic stenosis (AS), and 11 control subjects using an intravascular Doppler catheter with spectral analysis. Angiographic assessment of AR identified 10 patients with mild regurgitation and 16 with severe regurgitation. The resting systolic coronary flow velocity-time integral (VTI) was significantly higher and the diastolic VTI was slightly but significantly higher in patients with severe regurgitation than in those with mild regurgitation (11.8+/-4.2 vs 4.1+/-1.1 cm, P<.001; 18.5+/-5.8 vs 13.2+/-3.2 cm, P<.05) and control subjects (4.0+/-1.0 cm, P<.001 and 13.3+/-3.6 cm, P<.05), respectively. Patients with AS had a slightly lower resting systolic VTI (3.8+/-1.4 cm) and a higher diastolic VTI (14.6+/-3.7 cm) than control subjects. Resting coronary blood flow was greater in patients with aortic valve disease than in control subjects. There was a significant correlation between the ratio of the resting systolic to diastolic VTI (S/D ratio) and the ratio of the aortic systolic to diastolic pressure (r=.75, P<.001) in patients with AR. The S/D ratio was inversely correlated with left ventricular systolic pressure (r=-.92, P<.001) and positively correlated with the ratio of the aortic systolic to diastolic pressure (r=.68, P<.05) in patients with AS. Conclusions. Our results indicate that hemodynamic changes related to aortic valve disease contribute to alterations in the resting phasic coronary blood flow and velocity profiles observed in these patients.