MEAL-INDUCED C-FOS EXPRESSION IN BRAIN-STEM IS NOT DEPENDENT ON CHOLECYSTOKININ RELEASE

被引:71
作者
FRASER, KA [1 ]
DAVISON, JS [1 ]
机构
[1] UNIV CALGARY,DEPT MED PHYSIOL,GASTROINTESTINAL RES GRP,3330 HOSP DR NW,CALGARY T2N 4N1,AB,CANADA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 01期
关键词
NUCLEUS OF TRACTUS-SOLITARIUS; AREA POSTREMA; FOOD INTAKE;
D O I
10.1152/ajpregu.1993.265.1.R235
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Sprague-Dawley rats injected with a ''physiological'' dose of cholecystokinin octapeptide (CCK-8; 6 mug/kg ip) expressed c-fos immunoreactivity in the nucleus of the tractus solitarius (NTS) and the area postrema (AP) of the brain stem. Injection of the CCK-A antagonist L-364,718 30 min before CCK-8 injection eliminated c-fos expression in these regions. These findings support the hypothesis that CCK-8 induced c-fos expression is mediated by CCK-A receptors. We then tested whether a meal (Isocal) could activate c-fos, and, if so, whether this response could be eliminated by L-364,718. Ingestion of Isocal induced c-fos immunoreactivity in the NTS and AP. Meal-induced c-fos expression was not blocked by the CCK-A antagonist L-364,718. These findings demonstrate for the first time that a purely physiological nonnoxious stimulus, a meal, induces c-fos in the rat brain stem and indicate that feeding induces c-fos expression by a pathway that is largely, if not entirely, independent of CCK release.
引用
收藏
页码:R235 / R239
页数:5
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