CARDIOVASCULAR EFFECTS OF LONG-TERM ENDOTHELIN INFUSION AND RESPONSES TO ENDOTHELIN DURING ACTH INFUSION IN CONSCIOUS SHEEP

被引：9

作者：

MAY, CN

MATHAI, ML

MCDOUGALL, JG

WHITWORTH, JA

机构：

[1] Howard Florey Institute of Experimental Physiology and Medicine University of Melbourne, Parkville

[2] Department of Medicine, St. George Hospital, University of New South Wales

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 10期

基金：

英国医学研究理事会;

关键词：

CORTICOTROPIN; BLOOD PRESSURE; CARDIAC OUTPUT; ENDOTHELIN; SHEEP;

D O I：

10.1093/ajh/6.10.837

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Infusion of endothelin-1 (ET-1) (2000 pmol/h) into conscious sheep for 6 days caused a sustained increase in mean arterial pressure (MAP) of 19 +/- 1 mm Hg. This response was mediated by the vasoconstrictor effect of ET-1 and was accompanied by a fall in cardiac output. Plasma renin concentration fell throughout the infusion and atrial natriuretic peptide was increased on day 1 of ET-1 infusion. Hematocrit dramatically increased, probably mainly due to plasma loss resulting from the ET-1-induced increased capillary hydrostatic pressure. To determine whether increased pressor responsiveness to ET-1 played a role in the rise in MAP caused by corticotropin (ACTH), the responses to bolus doses of ET-1 were evaluated before ACTH and on days 3 and 5 of ACTH infusion (5 mug/kg/day). ACTH increased MAP from 71 +/- 2 to 87 +/- 3 mm Hg. On the control day ET-1 (400, 1200, and 2000 pmol) increased MAP by 5 +/- 1, 18 +/- 6 and 35 +/- 11 mm Hg, respectively. No initial vasodilation occurred. The responses to all doses of ET-1 were similar during ACTH infusion. Plasma levels of ET-1 did not increase during ACTH infusion. These results demonstrate that long-term infusion of ET-1 caused a sustained increase in blood pressure. There was no evidence that the sensitivity or responsiveness to ET-1 were altered during infusion of ACTH. In conclusion, ET-1 could play a role in the pathogenesis of hypertension but does not appear to be involved in the increase in blood pressure caused by ACTH.

引用

页码：837 / 843

页数：7

共 30 条

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