SYNTHESIS OF ETOPOSIDE PHOSPHATE, BMY-40481 - A WATER-SOLUBLE CLINICALLY ACTIVE PRODRUG OF ETOPOSIDE

被引:35
作者
SAULNIER, MG
LANGLEY, DR
KADOW, JF
SENTER, PD
KNIPE, JO
TUN, MM
VYAS, DM
DOYLE, TW
机构
[1] Bristol-Myers Squibb Company, Wallingford, CT 06492
关键词
D O I
10.1016/S0960-894X(01)80285-7
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Etoposide Phosphate (BMY-40481) is synthesized semisynthetically from the clinically approved anticancer parent drug, etoposide (VP-16-213), and also from natural (-)-epipodophyllotoxin. Etoposide phosphate functions as a clinically active, water soluble prodrug of etoposide. The NDA for etoposide phosphate was filed in June, 1994.
引用
收藏
页码:2567 / 2572
页数:6
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