SYNTHESIS OF ALPHA-MANNOSYLATED ERGOT ALKALOIDS EMPLOYING ALPHA-MANNOSIDASE

被引：14

作者：

SCIGELOVA, M ^{[1
]}

KREN, V ^{[1
]}

NILSSON, KGI ^{[1
]}

机构：

[1] LUND UNIV,CTR CHEM,DEPT BIOTECHNOL,S-22100 LUND,SWEDEN

来源：

BIOTECHNOLOGY LETTERS | 1994年 / 16卷 / 07期

关键词：

D O I：

10.1007/BF00136471

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The ergot alkaloids elymoclavine, ergometrine and chanoclavine were alpha-mannosylated with alpha-mannosidase as catalyst. The kinetic reaction with p-nitrophenyl alpha-mannoside as glycosyl donor gave ca 28 % yield of chanoclavine alpha-mannoside, whereas the equilibrium reaction with mannose as the glycosyl donor gave ca 11 % yield. However, in the case of elymoclavine and ergometrine, higher yields of alpha-mannosides were obtained with the equilibrium approach (18 and 13 %).

引用

页码：683 / 688

页数：6

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