A LONG-TERM, RANDOMIZED, COMPARATIVE-STUDY OF INSULIN VERSUS SULFONYLUREA THERAPY IN TYPE-2 DIABETES

Objectives. To study the effect of insulin and sulfonylurea (SU) therapy on glycaemic control, insulin resistance and cardiovascular risk factors in type 2 diabetic subjects. Design. A prospective, parallel, randomized, controlled, long-term study. Setting. Outpatient clinic in tertiary referral centre. Subjects. Thirty-six type 2 diabetic subjects treated with diet and SU, aged 44-69 years and a duration of diabetes of between 2 and 14 years. Interventions. Individually adjusted doses of insulin and glibenclamide. Main outcome measures. Glycosylated haemoglobin (HbA(1c)), insulin resistance (euglycaemic glucose clamp), levels of lipids, lipoproteins and blood pressure. Results. Glycaemic control improved during insulin treatment, but deteriorated on SU; HbA(1c) levels differed significantly between groups after 12 months of therapy (mean+/-SEM 7.9+/-0.3 vs. 9.5+/-0.4%, P = 0.004). Body mass index increased significantly during insulin treatment (26.4+/-0.7 to 27.8+/-0.7 kg/m(2), P = 0.0001) and 30% of this increase was a result of an increase in lean body mass. The total glucose disposal rate showed a small increase in the insulin group. Levels of triglycerides and apolipoprotein B were significantly reduced during insulin treatment (1.8+/-0.2 to 1.5+/-0.2 mmol L(-1), P = 0.03 and 1.58+/-0.1 to 1.40+/-0.08 g L(-1), P = 0.003), and insulin prevented a reduction in the levels of high-density lipoprotein (KDL) cholesterol and apolipoprotein A-1 and an increase in Lp(a) lipoprotein observed in the SU group. Blood pressure levels did not change during therapy. Conclusions. Insulin therapy was superior to SU treatment in achieving good metabolic control. Despite a modest improvement in cardiovascular risk factors in the insulin-treated group, no significant differences were observed between the groups after 1 year's treatment.