NEUTRALIZING EPITOPES OF SIMIAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEIN

被引：5

作者：

KENT, KA

机构：

[1] National Institute for Biological Standards and Controls, Potters Bar, Hertfordshire, Blanche Lane, South Mimms

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1995年 / 24卷 / 03期

关键词：

HIV; V2; V3; CONFORMATION-DEPENDENT EPITOPES;

D O I：

10.1111/j.1600-0684.1995.tb00160.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Monoclonal and polyclonal antibodies with weak SIV neutralising activity bind to the V2 and V4 regions of gp 120 or bind to the amino acids DWNND in gp41. Antibodies with the most potent neutralising activity recognise conformation-dependent epitopes involving the V3 and V4 regions of gp120. Monoclonal antibodies that map to the V3 region of SIVmac failed to neutralise. However, one antibody to SIV AGM neutralised but only in the presence of soluble CD4.

引用

页码：145 / 149

页数：5

共 41 条

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