Monoclonal and polyclonal antibodies with weak SIV neutralising activity bind to the V2 and V4 regions of gp 120 or bind to the amino acids DWNND in gp41. Antibodies with the most potent neutralising activity recognise conformation-dependent epitopes involving the V3 and V4 regions of gp120. Monoclonal antibodies that map to the V3 region of SIVmac failed to neutralise. However, one antibody to SIV AGM neutralised but only in the presence of soluble CD4.
机构:
HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772
BURNS, DPW
DESROSIERS, RC
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机构:
HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772
机构:
HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772
BURNS, DPW
DESROSIERS, RC
论文数: 0引用数: 0
h-index: 0
机构:
HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,1 PINE HILL DR,SOUTHBOROUGH,MA 01772