HIGHLY SELECTIVE IN VIVO ETHYLATION OF RAT LIVER NUCLEAR PROTEIN BY ETHIONINE

被引：55

作者：

FRIEDMAN, M

SHULL, KH

FARBER, E

机构：

[1] Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 34卷 / 06期

关键词：

D O I：

10.1016/0006-291X(69)90259-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ethionine ethylates rat liver nuclear proteins in a highly selective manner. The proteins most ethylated are those insoluble in 20-40% (NH4)2SO4 in the saline soluble fraction. With L-ethionine-ethyl-1-14C, only one peak of radioactivity was found. This peak has been tentatively identified as an ethyl analogue of methylguanidino arginine, recently reported to occur in nuclear proteins. No radioactive ethionine was found in the proteins after giving ethyl-labeled or 35S-labeled ethionine. The pattern of labeling with methionine-methyl-14C is more complex and is presented. © 1969.

引用

页码：857 / +

页数：1

共 12 条

[1]

DYER HELEN M., 1938, JOUR BIOL CHEM, V124, P519

[2] ETHIONINE CARCINOGENESIS [J].