QUANTITATIVE-ANALYSIS OF TETRACYCLINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON POLYSTYRENE-DIVINYLBENZENE PACKING MATERIALS

被引：46

作者：

KHAN, NH

WERA, P

ROETS, E

HOOGMARTENS, J

机构：

[1] Katholieke Universiteit Leuven, Laboratorium voor Farmaceutische Chemie, Instituut voor Farmaceutische Wetenschannen, Van Evenstraat 4 B-300, Leuven

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 07期

关键词：

D O I：

10.1080/01483919008049254

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Isocratic high-performance liquid chromatography on a poly(styrene-divinylbenzene)copolymer column allows the complete separation and resolution of tetracycline, 4-epitetracycline, anhydrotetracycline and 4-epianhydrotetracycline. A fermentation impurity, 2-acety1-2-decarboxamidotetracycline is also resolved from tetracycline. The mobile phase combines tert.-butanol, water and phosphate buffer, tetrabutylammonium sulphate and sodium ethylenediaminetetraacetate at a pH of 9.0 for elution at a temperature of 60 °C. The method was used to analyse official standards and commercial samples. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：1351 / 1374

页数：24

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