OXYGEN-HEMOGLOBULIN DISSOCIATION CURVES - EFFECT OF INHERITED ENZYME DEFECTS OF RED CELL

被引：94

作者：

DELIVORI.M

OSKI, FA

GOTTLIEB, AJ

机构：

[1] University of Pennsylvania, School of Medicine, Philadelphia

来源：

SCIENCE | 1969年 / 165卷 / 3893期

关键词：

D O I：

10.1126/science.165.3893.601

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The blood of a patient with a deficiency of hexokinase in the red cells and a decreased concentration of 2,3-diphosphoglycerate in the red cells showed an increased affinity for oxygen, whereas a patient with a deficiency of pyruvate kinase and an elevated concentration of 2,3-diphosphoglycerate in the red cells had blood with a decreased affinity for oxygen. Defects in red cell glycolysis may alter the oxygen affinity of blood by virtue of their effect on 2,3-diphosphoglycerate concentrations in red cells.

引用

页码：601 / &

共 14 条

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