GROWTH-REGULATION BY INSULIN-LIKE GROWTH-FACTORS IN LUNG-CANCER

被引：16

作者：

HAVEMANN, K

ROTSCH, M

SCHONEBERGER, HJ

ERBIL, C

HENNIG, C

JAQUES, G

机构：

[1] Department of Internal Medicine, Division of Hematology/Oncology, Philipps-University Marburg, D-3550 Marburg, Baldingerstrasse

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1990年 / 37卷 / 06期

关键词：

D O I：

10.1016/0960-0760(90)90436-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer is a major health problem, with over 38,000 new cases expected every year in West Germany. A more complete understanding of the biology of lung cancer will hopefully lead to therapeutic modalities. The possible autocrine growth regulation in small-cell lung cancer and non-small-cell lung cancer has been demonstrated for bombesin/GRP, vasopressin, neurotensin, EGF/TGF-alpha, transferrin-related peptides and insulin-like growth factors. This contribution concentrates on recent data concerning binding sites, growth promoting effects and secretion of IGFs in lung cancer cell lines. The production of IGF-binding proteins which were also produced by lung cancer cell lines modifies the autocrine/paracrine model for IGFs since then proteins can either enhance or inhibit the effect of IGFs on tumor growth.

引用

页码：877 / 882

页数：6

共 17 条

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