METABOLISM OF 2-CHLORO-N-ISOPROPYLACETANILIDE (PROPACHLOR) IN THE SHEEP AND MILK GOAT

被引：9

作者：

BAKKE, JE ^{[1
]}

PRICE, CE ^{[1
]}

机构：

[1] USDA SEA, METAB & RADIAT RES LAB, FARGO, ND 58102 USA

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 1979年 / 14卷 / 03期

关键词：

glucuronides; mercapturic acid pathway; metabolism; methylsulfonyl; propachlor;

D O I：

10.1080/03601237909372129

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Sheep metabolized a single oral dose of the herbicide 2-chloro-N-isopropylacetanilide (propachlor) to 4 urinary metabolites. These were 2-(S-cysteinyl)-N-isopropylacetanilide and 2-[S-(N-acetyl) cysteinyl]-N-isopropylacetanilide and the glucuronide conjugates of 4''-hydroxy-N-isopropyl-2-methylsulfonylacetanilide and N-(1-hydroxyisopropyl)-2-methylsulfonylacetanilide. Residues (ppb equivalents of propachlor) from [14C]-propachlor in the milk from a goat given daily oral doses (1.3 mg of propachlor 3 .times. daily for 15 days) plateaued at about 2-4 ppb equivalents of propachlor. In goat tissue, residues ranged from 1 ppb (fat) to 20 ppb (liver). Fecal and tissue metabolites were not identified.

引用

页码：291 / 304

页数：14

共 5 条

[1] REPLACEMENT OF A CHLORINE WITH A METHYLSULFONYL GROUP IN METABOLISM OF PROPACHLOR (2-CHLORO-N-ISOPROPYLACETANILIDE) [J].