PANCREATIC-POLYPEPTIDE AND PEPTIDE-YY INHIBIT THE DENERVATED CANINE PANCREAS

被引：15

作者：

DEMAR, AR ^{[1
]}

TAYLOR, IL ^{[1
]}

FINK, AS ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT SURG,LOS ANGELES,CA 90024

来源：

PANCREAS | 1991年 / 6卷 / 04期

关键词：

PANCREATIC POLYPEPTIDE; PANCREATIC INNERVATION; PANCREATIC SECRETION; PANCREATIC INHIBITION;

D O I：

10.1097/00006676-199107000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic polypeptide and peptide YY are inhibitors of pancreatic exocrine secretion in vivo but not in vitro, which suggests secondarily mediated mechanism(s) of action. To determine the role of extrinsic neural and intrinsic cholinergic elements on this inhibitory effect, a total of nine dogs underwent two-stage extrapancreatic denervation and creation of a chronic pancreatic fistula. After recovery, pancreatic polypeptide or peptide YY (400 pmol/kg/h) was administered during the intermediate hour of a 3-hour secretin (125 ng/kg/h)/cholecystokinin (50 ng/kg/h) infusion. Exocrine secretion during pancreatic polypeptide or peptide YY hours was compared with that of the first and third hours. The studies were then repeated during infusion of atropine (10-mu-g/kg/h). Despite extrinsic denervation, pancreatic polypeptide and peptide YY significantly inhibited secretin/cholecystokinin-induced pancreatic output. Although less profound, significant inhibition persisted in the presence of an atropine background. Pancreatic polypeptide or peptide YY infusion also decreased the exocrine response to meal stimulation. We conclude that the inhibitory effects of pancreatic polypeptide and peptide YY are not mediated by extrapancreatic, and possibly not by intrapancreatic cholinergic, neural pathways.

引用

页码：419 / 426

页数：8

共 32 条

[1]

Larsson L.I., Sundler F., Hakanson R., Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells, Cell Tissue Res, 156, pp. 167-171, (1975)

[2]

Adrian T.E., Fem G.-L., Bacarese-Hamilton A.J., Fuessl H.S., Polak J.M., Bloom S.R., Human distribution and release of a putative new gut hormone, peptide YY, Gastroenterology, 89, pp. 1070-1077, (1985)

[3]

Lundberg J.M., Tatemoto K., Terenius L., Et al., Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility, Proc Natl Acad Sci USA, 79, pp. 4471-4475, (1982)

[4]

Lluis F., Gomez G., Fujimura M., Greeley G.H., Thompson J.C., Peptide YY inhibits nutrient-, hormonal-, and vagally stimulated pancreatic exocrine secretion, Pancreas, 2, pp. 454-462, (1987)

[5]

Pappas T.N., Debas H.T., Goto Y., Taylor I.L., Peptide YY inhibits meal-stimulated pancreatic and gastric secretion, Am J Physiol, 248, pp. G118-G123, (1985)

[6]

Taylor I.L., Solomon T.E., Walsh J.H., Grossman M.I., Pancreatic polypeptide. Metabolism and effect on pancreatic secretion in dogs, Gastroenterology, 76, pp. 524-528, (1979)

[7]

Louie D.S., Williams J.A., Owyang C., Action of pancreatic polypeptide on rat pancreatic secretion in vivo and in vitro, Am J Physiol, 249, pp. 0489-0495, (1985)

[8]

Pan Lu G.-Z.L., Qian J.-M., Xue B.-G., Bovine pancreatic polypeptide as an antagonist of muscarinic cholinergic receptors, Am J Physiol, 252, pp. G384-G391, (1987)

[9]

Jung G., Louie D.S., Owyang C., Pancreatic polypeptide inhibits pancreatic enzyme secretion via a cholinergic pathway, Am J Physiol, 253, pp. G706-G710, (1987)

[10]

Fink A.S., Demar A.R., Gettys T.W., Taylor I.L., Meal-induced pancreatic polypeptide release in a validated pancreatic denervation model: A role for the distal pancreas?, Pancreas, 5, pp. 323-329, (1990)

← 1 2 3 4 →