ATP-DEPENDENT RECOGNITION OF EUKARYOTIC ORIGINS OF DNA-REPLICATION BY A MULTIPROTEIN COMPLEX

被引：1057

作者：

BELL, SP

STILLMAN, B

机构：

[1] Cold Spring Harbor Laboratory, Cold Spring Harbor

来源：

NATURE | 1992年 / 357卷 / 6374期

关键词：

D O I：

10.1038/357128a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A multiprotein complex that specifically recognizes cellular origins of DNA replication has been identified and purified from the yeast Saccharomyces cerevisiae. We observe a strong correlation between origin function and origin recognition by this activity. Interestingly, specific DNA binding by the origin recognition complex is dependent upon the addition of ATP. We propose that the origin recognition complex acts as the initiator protein for S. cerevisiae origins of DNA replication.

引用

页码：128 / 134

页数：7

共 46 条

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