RANDOMIZED SINGLE BLIND TRIAL TO COMPARE THE TOXICITY OF SUBCONJUNCTIVAL GENTAMICIN AND CEFUROXIME IN CATARACT-SURGERY

被引:26
作者
JENKINS, CDG [1 ]
MCDONNELL, PJ [1 ]
SPALTON, DJ [1 ]
机构
[1] ST THOMAS HOSP,DEPT OPHTHALMOL,MED EYE UNIT,LAMBETH PALACE RD,LONDON SE1 7EH,ENGLAND
关键词
D O I
10.1136/bjo.74.12.734
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients undergoing routine cataract surgery. Our results suggest that a hyperaemic eye is likely to occur about twice as often in patients injected with gentamicin (p<0.001). Gentamicin is associated with more pain postoperatively (p<0.05). Significant manifestations of gentamicin toxicity are conjunctival oedema and capillary closure. Cefuroxime has some theoretical advantages over gentamicin in its antibacterial spectrum.
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页码:734 / 738
页数:5
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