CHRONIC PRENATAL MORPHINE TREATMENT DECREASES G-ALPHA-S MESSENGER-RNA LEVELS IN NEONATAL FRONTAL-CORTEX

被引：14

作者：

BASHEER, R ^{[1
]}

JIAN, Y ^{[1
]}

TEMPEL, A ^{[1
]}

机构：

[1] ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,HILLSIDE HOSP,DEPT PSYCHIAT,LONG ISL CAMPUS,GLEN OAKS,NY 11004

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1992年 / 70卷 / 01期

关键词：

G-PROTEIN EXPRESSION; CENTRAL NERVOUS SYSTEM DEVELOPMENT; MORPHINE; TOLERANCE; NEONATE;

D O I：

10.1016/0165-3806(92)90113-B

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

G(alphas), mRNA levels were measured in brain regions of newborn pups following prenatal morphine treatment. A significant decrease (24%) in G(alphas), mRNA levels was observed in the frontal cortex. No changes were observed in other regions. This report demonstrates the first in vivo study of opiate effects on G-protein gene expression in neonates. The development of tolerance in vivo may involve complex interactions between several neurotransmitter systems having opposing actions on the G-protein system.

引用

页码：145 / 148

页数：4

共 30 条

[1] DIFFERENTIAL-EFFECTS OF CHRONIC MORPHINE AND NALOXONE ON OPIATE RECEPTORS, MONOAMINES, AND MORPHINE-INDUCED BEHAVIORS IN PREWEANLING RATS [J].