ENZYMATIC-SYNTHESIS OF OPTICALLY-ACTIVE (S)-(+)-2-HYDROXYMETHYL-3,4-DIHYDRO-2H-PYRAN AND (S)-(+)-2-ACETOXYMETHYL-3,4-DIHYDRO-2H-PYRAN

被引：13

作者：

KANG, SK

JEON, JH

YAMAGUCHI, T

HONG, RK

KO, BS

机构：

[1] Department of Chemistry, Sung Kyun Kwan University, Suwon, 440-746, Natural Science Campus

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 01期

关键词：

D O I：

10.1016/0957-4166(94)00361-E

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Porcine pancreas lipase(PPL)-catalyzed acetylation of(+/-)-2-hydroxymethyl-3,4-dihydro-2H-pyran with vinyl acetate in organic solvent afforded (S)-(+)-2-acetoxymethyl-3,4-dihydro-2H-pyran. Alternatively, (+/-)-2-acetoxymethyl-3,4-dihydro-2H-pyran was resolved via hydrolysis catalyzed by PPL in acetone-phosphate buffer system to afford (S)-(+)-2-hydroxymethyl-3,4-dihydro-2H-pyran with high enantiomeric purity.

引用

页码：97 / 100

页数：4

共 15 条

[1] STUDIES RELATED TO THE SYNTHESIS OF DERIVATIVES OF 2,6-DIAMINO-2,3,4,6-TETRADEOXY-D-ERYTHRO-HEXOSE (PURPUROSAMINE-C), A COMPONENT OF GENTAMICIN-C-1A [J].