THE PHOTOPHYSICAL PROPERTIES OF A RUTHENIUM-SUBSTITUTED PHTHALOCYANINE

被引:25
作者
CHARLESWORTH, P
TRUSCOTT, TG
BROOKS, RC
WILSON, BC
机构
[1] JOHNSON MATTHEY INC,BIOMED RES,W CHESTER,PA
[2] ONTARIO CANC INST,TORONTO,ON M4X 1K9,CANADA
[3] ONTARIO LASER & LIGHTWAVE RES CTR,TORONTO,ON M5S 1A7,CANADA
关键词
LASER FLASH PHOTOLYSIS; SINGLET OXYGEN; PHTHALOCYANINE; PHOTODYNAMIC THERAPY; PULSE RADIOLYSIS;
D O I
10.1016/1011-1344(94)07048-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Laser flash photolysis, pulse radiolysis and time-resolved near-IR luminescence were used to study the photoproperties of a novel water-soluble metallophthalocyanine with no peripheral substitution. The phthalocyanine induces a significant reduction in tumour size or complete tumour eradication by photodynamic therapy (PDT). Yet, although this phthalocyanine sensitizes the production of singlet oxygen with a quantum yield of 0.3 in methanol, the quantum yield of singlet oxygen production in air-saturated D2O is less than 0.01 (the detection limit of our equipment). This is explained in terms of the combined effect of the triplet state lifetime of the phthalocyanine (1.2 mu s in nitrogen-saturated methanol and 0.65 mu s in nitrogen-saturated water) and the near tenfold reduction in the oxygen concentration from methanol to water. Therefore we propose that, in aqueous solution, a non-singlet-oxygen-mediated mechanism, probably electron transfer, prevails and leads to the observed PDT effect.
引用
收藏
页码:277 / 282
页数:6
相关论文
共 22 条
  • [1] BIOLOGICAL-ACTIVITIES OF PHTHALOCYANINES .10. SYNTHESES AND ANALYSES OF SULFONATED PHTHALOCYANINES
    ALI, H
    LANGLOIS, R
    WAGNER, JR
    BRASSEUR, N
    PAQUETTE, B
    VANLIER, JE
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1988, 47 (05) : 713 - 717
  • [2] BOSSARD GE, UNPUB INORG CHEM
  • [3] BROOKS RC, 1993, P AM ASS CANCER RES, V34
  • [4] METAL PHTHALOCYANINES AND PORPHYRINS AS PHOTOSENSITIZERS FOR REDUCTION OF WATER TO HYDROGEN
    DARWENT, JR
    DOUGLAS, P
    HARRIMAN, A
    PORTER, G
    RICHOUX, MC
    [J]. COORDINATION CHEMISTRY REVIEWS, 1982, 44 (01) : 83 - 126
  • [5] DOLPHIN D, 1980, CAN J CHEM, V58, P1125, DOI 10.1139/v80-175
  • [6] FAR-RED-ABSORBING PHOTOSENSITIZERS - THEIR USE IN THE PHOTODYNAMIC THERAPY OF TUMORS
    JORI, G
    [J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1992, 62 (03) : 371 - 378
  • [7] PULSE RADIOLYSIS APPARATUS
    KEENE, JP
    [J]. JOURNAL OF SCIENTIFIC INSTRUMENTS, 1964, 41 (08): : 493 - &
  • [8] KRALJIC I, 1978, PHOTOCHEM PHOTOBIOL, V28, P577, DOI 10.1111/j.1751-1097.1978.tb06972.x
  • [9] BIOLOGICAL-ACTIVITIES OF PHTHALOCYANINES .4. TYPE-II SENSITIZED PHOTOOXIDATION OF L-TRYPTOPHAN AND CHOLESTEROL BY SULFONATED METALLO PHTHALOCYANINES
    LANGLOIS, R
    ALI, H
    BRASSEUR, N
    WAGNER, JR
    VANLIER, JE
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 44 (02) : 117 - 123
  • [10] REDOX POTENTIALS OF METAL PHTHALOCYANINES IN NON-AQUEOUS MEDIA
    LEVER, ABP
    WILSHIRE, JP
    [J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1976, 54 (15): : 2514 - 2516