NEUROBIOLOGY OF WITHDRAWAL MOTIVATION - EVIDENCE FOR 2 SEPARATE AVERSIVE EFFECTS PRODUCED IN MORPHINE-NAIVE VERSUS MORPHINE-DEPENDENT RATS BY BOTH NALOXONE AND SPONTANEOUS WITHDRAWAL

被引：53

作者：

BECHARA, A ^{[1
]}

NADER, K ^{[1
]}

VANDERKOOY, D ^{[1
]}

机构：

[1] UNIV TORONTO, FAC MED, DEPT ANAT & CELL BIOL, TORONTO, ON M5S 1A8, CANADA

来源：

BEHAVIORAL NEUROSCIENCE | 1995年 / 109卷 / 01期

关键词：

D O I：

10.1037/0735-7044.109.1.91

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In drug-naive rats, the rewarding effects of morphine are blocked by lesions of the tegmental pedunculopontine nucleus (TPP), but not by neuroleptics. In dependent rats (chronically treated with morphine), morphine reward is blocked by neuroleptics, but not by TPP lesions. Just as this activation of opiate receptors in naive versus dependent rats produces different mechanisms of reward, this study concludes that reduced opioid activity on these opiate receptors produces different mechanisms of aversion. Neuroleptics blocked the conditioned place aversions produced by naloxone and spontaneous withdrawal in morphine dependent, but not naive, rats, without attenuating the somatic withdrawal syndrome induced by naloxone in dependent rats. The researchers suggest that the aversive effects of endogenous opioid withdrawal in naive rats are mediated by different neural substrates than the aversive effects of exogenous opioid withdrawal in dependent rats.

引用

页码：91 / 105

页数：15

共 59 条

[1] NOVELTY-INDUCED PLACE PREFERENCE BEHAVIOR IN RATS - EFFECTS OF OPIATE AND DOPAMINERGIC DRUGS [J].

BARDO, MT ;

NEISEWANDER, JL ;

PIERCE, RC .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (03) :683-689

[2] OPPOSITE MOTIVATIONAL EFFECTS OF ENDOGENOUS OPIOIDS IN BRAIN AND PERIPHERY [J].

BECHARA, A ;

VANDERKOOY, D .

NATURE, 1985, 314 (6011) :533-534

[3] A SINGLE BRAIN-STEM SUBSTRATE MEDIATES THE MOTIVATIONAL EFFECTS OF BOTH OPIATES AND FOOD IN NONDEPRIVED RATS BUT NOT IN DEPRIVED RATS [J].

BECHARA, A ;

VANDERKOOY, D .

BEHAVIORAL NEUROSCIENCE, 1992, 106 (02) :351-363

[4] CHRONIC EXPOSURE TO MORPHINE DOES NOT ALTER THE NEURAL TISSUES SUBSERVING ITS ACUTE REWARDING PROPERTIES - APPARENT TOLERANCE IS OVERSHADOWING [J].

BECHARA, A ;

VANDERKOOY, D .

BEHAVIORAL NEUROSCIENCE, 1992, 106 (02) :364-373

[5]

BECHARA A, 1989, J NEUROSCI, V9, P3400

[6] NEUROBIOLOGY OF MOTIVATION - DOUBLE DISSOCIATION OF 2 MOTIVATIONAL MECHANISMS MEDIATING OPIATE REWARD IN DRUG-NAIVE VERSUS DRUG-DEPENDENT ANIMALS [J].

BECHARA, A ;

HARRINGTON, F ;

NADER, K ;

VANDERKOOY, D .

BEHAVIORAL NEUROSCIENCE, 1992, 106 (05) :798-807

[7]

BECHARA A, 1986, SOC NEUR ABSTR, V12, P254

[8] RAPID INDUCTION AND QUANTITATION OF MORPHINE-DEPENDENCE IN RAT BY PELLET IMPLANTATION [J].

BHARGAVA, HN .

PSYCHOPHARMACOLOGY, 1977, 52 (01) :55-62

[9]

BLASIG J, 1973, PSYCHOPHARMACOLOGIA, V33, P19

[10] HEROIN REWARD IS DEPENDENT ON A DOPAMINERGIC SUBSTRATE [J].

BOZARTH, MA ;

WISE, RA .

LIFE SCIENCES, 1981, 29 (18) :1881-1886

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