LARGE-SCALE CLINICAL-EVALUATION OF BOWEL CONTRAST AGENT CONTAINING FERRIC AMMONIUM CITRATE IN MRI

被引：26

作者：

HIROHASHI, S

UCHIDA, H

YOSHIKAWA, K

FUJITA, N

OHTOMO, K

YUASA, Y

KAWAMURA, Y

MATSUI, O

机构：

[1] Department of Radiology, Nara Medical University, Kashihara-shi, Nara-ken

[2] Department of Radiology, Kanto Rosai Hospital, 2035 Nakahara-ku, Kawasaki-shi, Kanagawa-ken, Kizuki sumiyoshi-cho

[3] Department of Radiology, Hokkaido University Medical School, Hokkaido, N14 W5, Kita-ku, Sapporo-shi

[4] Department of Radiology, Yamanashi Medical School, Nakakoma-gun, Yamanashi-ken, Tamaho-mura

[5] Department of Radiology, Keio University, 35 Shinanomachi, shinjuku-ku, Tokyo-to

[6] Department of Radiology, Fukui Medical School, Yoshidagun, Fukui-ken, 23 Shimoaizuki, Matsuoka-cho

[7] Department of Radiology, Kanazawa University, Kanazawa-shi, Ishikawa-ken

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 06期

关键词：

MAGNETIC RESONANCE; CONTRAST MEDIA; GASTROINTESTINAL TRACT; FERRIC AMMONIUM CITRATE; FERRISELTZ;

D O I：

10.1016/0730-725X(94)92024-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Clear identification of bowel has been thought to be essential in diagnosis by abdominal MRI. We have completed the clinical phase III trial of a new oral contrast agent (FerriSeltz) which is a ferric ammonium citrate based bowel contrast agent. FerriSeltz is a powder that is dissolved in 300 ml water to create a grape-flavored effervescent drink. We have evaluated the usefulness of FerriSeltz, and compared groups receiving 600 mg and 1200 mg of ferric ammonium citrate, the use and nonuse of parasympathetic blockers, and patients with and without fasting in 174 patients who underwent abdominal MRI using this agent. FerriSeltz was found to brighten the stomach and duodenum, contribute to the improvement in diagnostic efficacy, be safe as a bowel contrast agent in abdominal MRI, and be associated with an extremely low incidence of side effects (only mild diarrhea in one of 169 patients). No significant differences were found in the contribution to the improvement in diagnostic efficacy between the two dosage groups, the use and nonuse of parasympathetic blockers, or patients with and without fasting. We concluded that ferric ammonium citrate based compound (FerriSeltz) is a promising bowel contrast agent in abdominal MRI.

引用

页码：837 / 846

页数：10

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