NUCLEOTIDE-SEQUENCE OF THE GENE CODING FOR THE MAJOR PROTEIN OF HEPATITIS-B VIRUS SURFACE-ANTIGEN

被引：288

作者：

VALENZUELA, P

GRAY, P

QUIROGA, M

ZALDIVAR, J

GOODMAN, HM

RUTTER, WJ

机构：

[1] Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco

来源：

NATURE | 1979年 / 280卷 / 5725期

关键词：

D O I：

10.1038/280815a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA extracted from hepatitis B virus Dane particles has been cloned in bacteria using a plasmid vector. A full-length clone has been examined by restriction endonuclease analysis, and the nucleotide sequence of an 892-base pair fragment from cloned hepatitis B viral DNA encoding the surface antigen gene is reported. The amino acid sequence deduced from the DNA indicates that the surface antigen is a protein consisting of 226 amino acids and with a molecular weight of 25,398. The portion of the gene coding for this protein apparently contains no intervening sequences. © 1979 Nature Publishing Group.

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页码：815 / 819

页数：5

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