EFFECTS OF 2-DEOXY-D-GLUCOSE ON SCHEDULE DEPENDENT AND SCHEDULE-INDUCED BEHAVIOR AND INGESTION AT DIFFERENT BODY WEIGHTS

The effects of intraperitoneally administered 2-deoxy-D-glucose (2DG) at 0, 50, 150, 300 and 600 mg/kg, were studied in four experiments. Experiments 1 and 2 determined the effects of 2DG on schedule induced licking and drinking and schedule dependent lever pressing in rats maintained at 80% and ad lib free feeding body weights during 3 hr on an FI-1 min food reinforcement schedule. Experiments 3 and 4 evaluated the effects of 2DG on free access home cage food and water consumption under the same body weight conditions. Decreases in food and water consumption were observed under both feeding conditions when animals were reduced to 80% free feeding body weight. At ad lib feeding body weight, 2DG administration had no effects on licking, drinking, and lever pressing during FI-1 min scheduled food reinforcement or on free access home cage feeding and drinking. The effects of 2DG on ingestive behavior are discussed in terms of central and peripheral glucosensitive cells and the consequences of blocking glucose utilization at different body weights under different stimulus conditions. © 1979.