PRODUCTION OF HUMAN TO MOUSE XENOGRAFTS BY UMBILICAL-CORD BLOOD

被引：7

作者：

ENDE, N

GIULIANI, D

ENDE, M

PONZIO, NM

机构：

[1] Department of Pathology University of Medicine and Dentistry, New Jersey New Jersey Medical School, Newark

来源：

LIFE SCIENCES | 1990年 / 46卷 / 19期

关键词：

D O I：

10.1016/0024-3205(90)90337-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Utilizing human umbilical cord blood, it has been possible to create in irradiated animals a human to mouse xenograft. To facilitate hematopoietic reconstitution, SJL/J mice, which are functionally low in natural killer (NK) cells, were treated with anti-Asialo GM1 antibodies (anti-NK) and irradiation prior to injection of cord blood mononuclear cells. In contrast, SJL/J mice with the "beige" (bg/bg) mutation, which confers a functional NK cell deficiency, required only irradiation for successful transplantation. Human cells, detected by means of DNA probes, were demonstrated in the lungs and lymph nodes of irradiated animals up to 6 months after injection of the human cord blood cells. © 1990.

引用

页码：1373 / 1380

页数：8

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