HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 IN ORGANOTYPIC CULTURES OF MOUSE CENTRAL AND PERIPHERAL NERVOUS-SYSTEM .2. ELECTRON-MICROSCOPIC OBSERVATIONS OF MYELIN DEGENERATION

被引:11
作者
ECOBJOHNSTON, MS [1 ]
ELIZAN, T [1 ]
SCHWARTZ, J [1 ]
WHETSELL, WO [1 ]
机构
[1] CUNY,MT SINAI SCH MED,NEUROVIROL LAB,NEW YORK,NY 10029
关键词
D O I
10.1097/00005072-197901000-00002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Organotypic cultures of mouse spinal cord with attached dorsal root ganglia, which contain both central and peripheral myelin in the one unit of tissue, were infected with HSV 1 or HSV 2 and studied using electron microscopy. Intranuclear viral nucleocapsids and intracytoplasmic enveloped particles were found in the Schwann cells associated with peripheral myelin and in oligodendroglia associated with central myelin. Degeneration of peripheral myelin most commonly involved an asymmetrical swelling of the myelin lamellae, whereas degeneration of central myelin was characterized by a more generalized swelling resulting in separation of the myelin lamellae. Degeneration of both central and peripheral myelin was found in the presence of intact axons which were indistinguishable from those in controls. © 1979 American Association of Neuropathologists, Inc.
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页码:10 / 18
页数:9
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