INEFFECTIVENESS OF TOPICAL ADENINE-ARABINOSIDE 5'-MONOPHOSPHATE IN THE TREATMENT OF RECURRENT HERPES-SIMPLEX LABIALIS

被引:61
作者
SPRUANCE, SL
CRUMPACKER, CS
HAINES, H
BADER, C
MEHR, K
MACCALMAN, J
SCHNIPPER, LE
KLAUBER, MR
OVERALL, JC
机构
[1] UNIV UTAH, COLL MED, DEPT MED, DIV INFECT DIS, SALT LAKE CITY, UT 84132 USA
[2] UNIV UTAH, COLL MED, DEPT MED, DIV DERMATOL, SALT LAKE CITY, UT 84132 USA
[3] UNIV UTAH, COLL MED, DEPT PEDIAT, DIV INFECT DIS, SALT LAKE CITY, UT 84132 USA
[4] HARVARD UNIV, BETH ISRAEL HOSP,SCH MED,DEPT MED,DIV INFECT DIS, BOSTON, MA 02215 USA
[5] HARVARD UNIV, BETH ISRAEL HOSP, SCH MED, DEPT DERMATOL, BOSTON, MA 02215 USA
[6] UNIV MIAMI, SCH MED, DEPT DERMATOL, MIAMI, FL 33152 USA
[7] UNIV CALIF SAN DIEGO, DEPT COMMUNITY MED, LA JOLLA, CA 92093 USA
关键词
D O I
10.1056/NEJM197905243002103
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The ability of topical 10 per cent adenine arabinoside 5′-monophosphate to decrease the severity and frequency of recurrent herpes simplex labialis was evaluated in a double-blind, randomized study of 233 patients at three collaborating institutions. Nine clinical and four virologic measurements were used to evaluate drug efficacy during a single episode. No statistically significant improvement in any measurement was seen in the drug-treated patients. Analyses according to institution and age, stage and size of lesion before therapy also indicated no benefit attributable to the drug. There was no effect of the drug on the rate of recurrence of herpes simplex labialis. We conclude that, despite activity against herpes simplex virus infection in tissue culture and in some laboratory animal models, topical use of the drug is ineffective against recurrent herpes simplex labialis. This may be due to failure of the drug to penetrate the skin. (N Engl J Med 300:1180–1184, 1979) RECURRENT herpes simplex labialis is thought to affect between 20 and 45 per cent of the United States’ population, and almost 25 per cent of those afflicted will have recurrences that are frequent or severe or both.1 Many forms of therapy have been tried,2 3 4 5 6 7 8 9 10 11 12 but none has had a statistically significant benefit on the course of herpes simplex labialis in a placebo-controlled, double-blind trial. Failure to demonstrate efficacy or unwarranted, premature conclusions concerning efficacy in previous clinical trials may have occurred for several reasons1: First, treatment was begun too late in the course of the disease to exert a. © 1979, Massachusetts Medical Society. All rights reserved.
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页码:1180 / 1184
页数:5
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