HIGH-DENSITY-LIPOPROTEIN ANTAGONIZES THE INHIBITORY EFFECTS OF OXIDIZED LOW-DENSITY-LIPOPROTEIN AND LYSOLECITHIN ON SOLUBLE GUANYLYL CYCLASE

被引：28

作者：

SCHMIDT, K ^{[1
]}

KLATT, P ^{[1
]}

GRAIER, WF ^{[1
]}

KOSTNER, GM ^{[1
]}

KUKOVETZ, WR ^{[1
]}

机构：

[1] GRAZ UNIV,INST MED BIOCHEM,A-8010 GRAZ,AUSTRIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80145-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidatively modified LDL (LDLox) reduces the response of soluble guanylyl cyclase to nitrovasodilators. We now demonstrate that this desensitization can be antagonized by HDL. Similar to its protective effect against LDLox, HDL also inhibited the lysolecithin-induced desensitization of soluble guanylyl cyclase. Since the lysolecithin content of LDLox correlated with the amount of lysolecithin necessary to diminish stimulation of soluble guanylyl cyclase, our data support the hypothesis that lysolecithin may be responsible for the inhibitory effect of LDLox on smooth muscle relaxation and provide evidence that the antagonistic effect of HDL against desensitization of soluble guanylyl cyclase by atherogenic compounds could be responsible for the protective role of HDL in atherosclerosis. © 1992 Academic Press, Inc.

引用

页码：302 / 308

页数：7

共 22 条

[1] HDL METABOLISM AND ATHEROSCLEROSIS [J].