INDUCTION OF MICRONUCLEI BY BLEOMYCIN IN G0 HUMAN-LYMPHOCYTES .2. POTENTIATION BY RADIOPROTECTORS

被引：18

作者：

HOFFMANN, GR ^{[1
]}

COLYER, SP ^{[1
]}

LITTLEFIELD, LG ^{[1
]}

机构：

[1] OAK RIDGE ASSOCIATED UNIV,DIV MED SCI,OAK RIDGE,TN 37830

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1993年 / 21卷 / 02期

关键词：

DIMETHYLSULFOXIDE; WR-1065; CYTOCHALASIN-B;

D O I：

10.1002/em.2850210207

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Dimethylsulfoxide (DMSO) and WR-1065 are radioprotectors, in that they reduce the effectiveness with which ionizing radiation causes genetic damage. Unlike their protective effects with radiation, these agents potentiate the induction of micronuclei by bleomycin in the cytokinesis-block assay in G0 human lymphocytes. High concentrations of DMSO (1 M) are required to cause potentiation. In contrast, WR-1065 causes dose-dependent potentiation at relatively low concentrations (1.25 to 10 mM). Cytogenetic analysis supports the results from the micronucleus assay, showing higher levels of genetic damage induced by the combination of bleomycin with DMSO or WR-1065 than by bleomycin alone. Possible mechanisms of potentiation are proposed.

引用

页码：136 / 143

页数：8

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