TIME-DEPENDENT RHEOLOGICAL BEHAVIOR OF BLOOD AT LOW SHEAR IN NARROW VERTICAL TUBES

被引:52
作者
ALONSO, C
PRIES, AR
GAEHTGENS, P
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 02期
关键词
BLOOD VISCOSITY; RED CELL AGGREGATION; LOW-SHEAR FLOW; MARGINAL PLASMA LAYER;
D O I
10.1152/ajpheart.1993.265.2.H553
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The time-dependent flow behavior of normal human blood after a sudden reduction of wall shear stress from 5,000 mPa to a low level (2-100 mPa) was studied during perfusion of vertical tubes (internal diam 28-101 mum) at constant driving pressures. Immediately after the implementation of low-shear flow conditions the concentration of red blood cells (RBCs) near the tube wall started to decrease, and marginal plasma spaces developed as a result of the assembly of RBC aggregates. This was associated with a time-dependent increase of flow velocity by up to 200% within 300 s, reflecting a reduction of apparent viscosity. These time-dependent changes of flow behavior increased strongly with decreasing wall shear stress and with increasing tube diameter. A correlation between the width of the marginal plasma layer and relative apparent viscosity was obtained for every condition of tube diameter, wall shear stress, and time. Time-dependent changes of blood rheological properties could be relevant in the circulation, where the blood is exposed to rapid and repeated transitions from high-shear flow conditions in the arterial and capillary system to low-shear conditions in the venous system.
引用
收藏
页码:H553 / H561
页数:9
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