ALTERNATE EXON USAGE IS A COMMONLY USED MECHANISM FOR INCREASING CODING DIVERSITY WITHIN GENES-CODING FOR EXTRACELLULAR-MATRIX PROTEINS

被引：49

作者：

BOYD, CD

PIERCE, RA

SCHWARZBAUER, JE

DOEGE, K

SANDELL, LJ

机构：

[1] WASHINGTON UNIV, JEWISH HOSP, MED CTR, DEPT MED, ST LOUIS, MO 63110 USA

[2] PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA

[3] SHRINERS HOSP CRIPPLED CHILDREN, RES UNIT, PORTLAND, OR 97201 USA

[4] UNIV WASHINGTON, DEPT ORTHOPAED & BIOCHEM, SEATTLE, WA 98195 USA

[5] VET ADM MED CTR, SEATTLE, WA 98108 USA

来源：

MATRIX | 1993年 / 13卷 / 06期

关键词：

ALTERNATE EXON USAGE; CODING DIVERSITY; EXTRACELLULAR MATRIX PROTEINS;

D O I：

10.1016/S0934-8832(11)80112-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Extracellular matrix proteins are a diverse family of secreted proteins and glycoproteins that are responsible for a variety of critical functions in different tissues. A large number of multiexon genes encode these proteins of the extracellular matrix. Over the last few years, it has become evident that the processing of the pre-mRNA from several of these genes involves alternative splicing. This review summarizes the known examples of alternative splicing in genes coding for the extracellular matrix and attempts to relate the increase in coding diversity generated by alternate exon usage to the function(s) of individual extracellular matrix proteins.

引用

页码：457 / 469

页数：13

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