POTASSIUM CHANNEL OPENER, RP-66471, INDUCES MEMBRANE DEPOLARIZATION OF RAT-LIVER MITOCHONDRIA

被引：55

作者：

SZEWCZYK, A ^{[1
]}

WOJCIK, G ^{[1
]}

NALECZ, MJ ^{[1
]}

机构：

[1] M NENCKI INST EXPTL BIOL,DEPT MUSCLE BIOCHEM,PL-02093 WARSAW,POLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 207卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effect of potassium channel openers on membrane potential of rat liver mitochondria was studied. It has been found that potassium channel opener RP 65471 induces depolarization of the mitochondrial membrane. Since neither the inhibition of mitochondrial respiration nor the uncoupling of mitochondria was observed concomitantly, the specific effect on the mitochondrial potential is postulated. Most likely the effect is caused by the increase of permeability of the inner mitochondrial membrane to potassium ions. Interestingly, however, it was found that no other potassium channel openers tested but RP 66471 was able to induce depolarization of mitochondrial membrane. (C) 1995 Academic Press, Inc.

引用

页码：126 / 132

页数：7

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