CHEMILUMINESCENT DETERMINATION OF 6-MERCAPTOPURINE IN PHARMACEUTICAL PREPARATION

被引：29

作者：

HE, ZK

LIU, XL

LUO, QY

YU, XM

ZENG, YE

机构：

[1] Department of Chemistry, Wuhan University

来源：

ANALYTICAL SCIENCES | 1995年 / 11卷 / 03期

关键词：

CHEMILUMINESCENCE; 6-MERCAPTOPURINE; TRIS(2,2'-BIPYRIDINE)RUTHENIUM(II);

D O I：

10.2116/analsci.11.415

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new chemiluminescence method is described for the determination of 6-mercaptopurine. In the presence of tris(2,2'-bipyridine)ruthenium(II), 6-mercaptopurine (6MP) and hydrogen peroxide, upon the addition of hydroxide ion, resulted in intense light emission. The emission intensity is greatly enhanced by the presence of Tween-20. The linear range and detection limit of 6MP are 1.4X10(-5)-1.4X10(-8) g/ml and 3X10(-10) g/ml, respectively. The method was evaluated by carrying out an interference study with common excipients and other coexisting compounds, by a recovery study and by the analysis of commercial formulation. A satisfactory result was obtained.

引用

页码：415 / 417

页数：3

共 10 条

[1]

BRUNE SN, 1991, TALANTA, V4, P419

[2] CHEMILUMINESCENCE DETECTION USING REGENERABLE TRIS(2,2'-BIPYRIDYL)RUTHENIUM(II) IMMOBILIZED IN NAFION [J].