ESTABLISHMENT OF A KARYOTYPICALLY NORMAL B-CHRONIC LYMPHOCYTIC-LEUKEMIA CELL-LINE - EVIDENCE OF LEUKEMIC ORIGIN BY IMMUNOGLOBULIN GENE REARRANGEMENT

被引：40

作者：

SALTMAN, D

BANSAL, NS

ROSS, FM

ROSS, JA

TURNER, G

GUY, K

机构：

[1] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

[2] WESTERN GEN HOSP,DEPT HEMATOL,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

LEUKEMIA RESEARCH | 1990年 / 14卷 / 04期

基金：

英国医学研究理事会;

关键词：

cell line; Chronic lymphocytic leukemia; immunoglobulin genes;

D O I：

10.1016/0145-2126(90)90167-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new Epstein-Barr virus (EBV) transformed cell line was established from a patient with B-chronic lymphocytic leukemia (B-CLL). The karyotype of the cell line has remained normal for over 12 months in culture; however, identical heavy and light chain immunoglobulin (Ig) gene rearrangements in the patient's blood and the cell line provided evidence that the EBV transformed cells were derived from the neoplastic clone. © 1990.

引用

收藏

页码：381 / 387

页数：7

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