COMPARISON OF THEOPHYLLINE AND ENPROFYLLINE EFFECTS ON HUMAN NEUTROPHIL SUPEROXIDE PRODUCTION

被引：17

作者：

KANEKO, M ^{[1
]}

SUZUKI, K ^{[1
]}

FURUI, H ^{[1
]}

TAKAGI, K ^{[1
]}

SATAKE, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 2,TSURUMA CHO,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 12期

关键词：

ADENOSINE; ENPROFYLLINE; NEUTROPHILS; SUPEROXIDE PRODUCTION; THEOPHYLLINE;

D O I：

10.1111/j.1440-1681.1990.tb01288.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. We investigated effects of theophylline (widely used for the treatment of asthma) and enprofylline (a new xanthine derivative with negligible adenosine antagonism) on O2- production by human neutrophils with n-formyl-methionylleucyl-phenylalanine (FMLP) stimulation. 2. Therapeutic concentrations of theophylline (1-100-mu-mol/L) enhanced O2- production, maximally by 43.1 +/- 24.4% at 30-mu-mol/L; the same concentrations of emprofylline inhibited O2- production. 3. When each agent was administered after pre-incubation with adenosine deaminase (ADA) (0.1 U/mL), O2- production was inhibited in a concentration-dependent manner in comparison with that under administration of ADA alone. 4. These results suggest that the difference of effects in the two xanthine derivatives at therapeutic concentrations might be due to the presence or absence of adenosine antagonism.

引用

页码：849 / 859

页数：11

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