TRIGGERED ACTIVITY AS A POSSIBLE MECHANISM FOR ARRHYTHMIAS IN VENTRICULAR HYPERTROPHY

被引:11
作者
CHARPENTIER, F
BAUDET, S
LEMAREC, H
机构
[1] UNIV NANTES,CARDIOL LAB,F-44035 NANTES,FRANCE
[2] UNIV NANTES,GEN PHYSIOL LAB,F-44035 NANTES,FRANCE
来源
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | 1991年 / 14卷 / 11期
关键词
DELAYED AFTERDEPOLARIZATIONS; TRIGGERED ACTIVITY; CARDIAC HYPERTROPHY; ARRHYTHMIAS; CALCIUM HOMEOSTASIS; BETA-ADRENERGIC STIMULATION;
D O I
10.1111/j.1540-8159.1991.tb02756.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To study the cellular mechanisms of arrhythmias occurring in cardiac hypertrophy, we performed standard microelectrode studies on papillary muscles isolated from control (group N) and hypertrophied ferrets right ventricles. Different stages of hypertrophy, induced by pulmonary banding, were studied: 10-22 days (group H1), 4-6 weeks (H2), and 5 1/2-6 months (H3). During the development of hypertrophy, under beta-adrenergic stimulation, triggered activity (TA) induced by delayed afterdepolarizations appeared in 2 of 5 muscles in group H1 and 8 of 8 in group H2. This arrhythmia was absent in N muscles, as well as in H3, despite a pronounced prolongation of the action potentials at 50% (100 +/- 9.3 msec in group H3 vs 67 +/- 5.7 msec in H2; P < 0.01) and 90% of repolarization (225 +/- 8.7 in H3 vs 185 +/- 7.4 msec in H2; P < 0.02). The presence of TA was associated with an increase in the intracellular calcium activity (144 +/- 60 nM in H2 vs 47 +/- 9 nM in N; P < 0.05). TA properties were as follows. Triggering frequency increased as beta-adrenergic stimulation increased, as pacing cycle length (PCL) decreased, and as duration of the prestimulative pause increased. The duration of salvos of TA increased as duration of the prestimulative pauses increased (NS). The coupling interval of the first triggered beat decreased as PCL decreased (P < 0.001). The minimal cycle length of salvos of TA was not modified by these parameters. It is concluded that delayed afterdepolarizations-induced TA may occur under beta-adrenergic stimulation during the first stages of ventricular hypertrophy. This could partly explain the occurrence of adrenergic-dependent arrhythmias in ventricular hypertrophy.
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页码:1735 / 1741
页数:7
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