ACCUMULATION OF ORNITHINE DECARBOXYLASE MESSENGER-RNA ACCOMPANIES ACTIVATION OF HUMAN AND MOUSE MONOCYTES MACROPHAGES

被引：21

作者：

MESSINA, L

ARCIDIACONO, A

SPAMPINATO, G

MALAGUARNERA, L

BERTON, G

KACZMAREK, L

MESSINA, A

机构：

[1] UNIV CATANIA,INST GEN PATHOL,VIA ANDRONE 83,I-95124 CATANIA,ITALY

[2] UNIV VERONA,INST GEN PATHOL,I-37100 VERONA,ITALY

[3] M NENCKI INST EXPTL BIOL,TISSUE CULTURE FACIL,PL-02093 WARSAW,POLAND

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Interferon-γ; Lipopolysaccharide; Macrophage activation; Ornithine decarboxylase;

D O I：

10.1016/0014-5793(90)80965-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulation of ornithine decarboxylase (ODC) mRNA was investigated in human monocytes and mouse peritoneal macrophages. Treatment of both populations of mononuclear phagocytes with bacterial lipopolysaccharide induced a marked and rapid increase in the accumulation of the ODC gene transcript. A similar phenomenon, albeit less pronounced, was also observed following treatment of human monocytes with human recombinant interferon-γ. These results suggest a role for ODC, and therefore polyamines, in the regulation of mononuclear phagocyte functions. © 1990.

引用

页码：32 / 34

页数：3

共 12 条

[1] BACTERIAL LIPOPOLYSACCHARIDES PRIME MACROPHAGES FOR ENHANCED RELEASE OF ARACHIDONIC-ACID METABOLITES [J].