HEPATOCYTE TRANSPLANTATION - A POTENTIAL TREATMENT FOR LIVER-DISEASE

被引:38
作者
DEMETRIOU, AA
FELCHER, A
MOSCIONI, AD
机构
[1] VANDERBILT UNIV,MED CTR,SCH MED,SR LIGHT SURG RES LAB,NASHVILLE,TN 37232
[2] VANDERBILT UNIV,MED CTR,SCH MED,DEPT SURG,NASHVILLE,TN 37232
关键词
HEPATOCYTES; TRANSPLANTATION; MICROCARRIERS; COLLAGEN;
D O I
10.1007/BF01307530
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The purpose of this report is to summarize data collected over the past several years in the field of hepatocyte transplantation. Herein, a novel method of intraperitoneal transplantation of hepatocytes attached to collagen-coated microcarriers (or a totally biodegradable collagen sponge) is described, resulting in correction of specific genetic liver defects in rats and improved survival in rats undergoing 90% partial hepatectomy. Transplanted cells/matrix form well-vascularized aggregates in the peritoneal cavity; transplanted hepatocytes can be identified by light microscopy using immunohistochemical methods. Prolongation of transplanted hepatocyte survival and function was demonstrated by pretreatment of cells with ultraviolet irradiation. The ability of transplanted cells to proliferate was examined using both biochemical and morphologic criteria. Finally, a method of harvesting, cryopreserving, and in vivo functional testing of human hepatocytes is described.
引用
收藏
页码:1320 / 1326
页数:7
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