CONVERSION OF (-)-4-HYDROXY-2-OXABICYCLO[3.3.0]OCT-7-EN-3-ONE INTO THE ANTI-HIV AGENT CARBOVIR

被引：52

作者：

MACKEITH, RA ^{[1
]}

MCCAGUE, R ^{[1
]}

OLIVO, HF ^{[1
]}

PALMER, CF ^{[1
]}

ROBERTS, SM ^{[1
]}

机构：

[1] CHIROS LTD,SCI PK,CAMBRIDGE CB4 4WE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 03期

关键词：

D O I：

10.1039/p19930000313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lactone (+/-)-1 was resolved using Pseudomonas fluorescens lipase and vinyl acetate; the ester (-)-3 obtained by this process was subsequently converted into the anti-HIV agent carbovir (-)-9.

引用

页码：313 / 314

页数：2

共 9 条

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