A PRACTICAL APPROACH TO THE SYNTHESIS OF C-14-LABELED AMINO-ACID AND SIMPLE PEPTIDE

被引：2

作者：

EKHATO, IV

HUANG, CC

机构：

[1] Radiochemistry, Dept. of Chemical Development, Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 02期

关键词：

INTESTINAL PEPTIDE TRANSPORTER; CACO-2 CELL LINE; N-GLYCYL-N-METHYL[CARBOXY-C-14]GLYCINE; ORGANOSTANNANE COMPOUND; AND TRANSMETALATION;

D O I：

10.1002/jlcr.2580340202

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A convenient method for the synthesis of phenylmethyl N-methyl[carboxy-C-14]glycine hydrochloride (7) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino acid 7 enabled us to synthesize target N-glycyl-N-methyl[carboxy-C-14]glycine 10 by conventional coupling protocol.

引用

页码：107 / 115

页数：9

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