THE CELLULAR PRION PROTEIN (PRP) SELECTIVELY BINDS TO BCL-2 IN THE YEAST 2-HYBRID SYSTEM

被引：115

作者：

KURSCHNER, C ^{[1
]}

MORGAN, JI ^{[1
]}

机构：

[1] ROCHE INST MOLEC BIOL, ROCHE RES CTR, NUTLEY, NJ 07110 USA

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 30卷 / 01期

关键词：

BCL-2; BAX; PRION PROTEIN; NEURODEGENERATION; 2 HYBRID SYSTEM; GERSTMANN-STRAUSSLER SYNDROME;

D O I：

10.1016/0169-328X(95)00013-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bcl-2 can rescue neurons from death and might, therefore, exert its action by associating with neuron-specific proteins. Using LexA-Bcl-2 as bait, we find that the cellular prion protein (PrP) interacts with Bcl-2, but not Bax. in the yeast two-hybrid system. Since the PrP gene has been implicated in neurodegenerative disorders, this preliminary observation suggests a potential pathogenic mechanism for these conditions.

引用

页码：165 / 168

页数：4

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