MODIFICATIONS OF THE EXTRACELLULAR-MATRIX OF ANEURYSMAL ABDOMINAL AORTAS AS A FUNCTION OF THEIR SIZE

被引：91

作者：

SAKALIHASAN, N ^{[1
]}

HEYERES, A ^{[1
]}

NUSGENS, BV ^{[1
]}

LIMET, R ^{[1
]}

LAPIERE, CM ^{[1
]}

机构：

[1] CHU SART TILMAN,DEPT DERMATOL,B35,B-4000 SART,BELGIUM

来源：

EUROPEAN JOURNAL OF VASCULAR SURGERY | 1993年 / 7卷 / 06期

关键词：

AORTIC ANEURYSMS; RUPTURED AAA; EXTRACELLULAR MATRIX; ELASTIN; COLLAGEN;

D O I：

10.1016/S0950-821X(05)80708-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Collagen and elastin are the main extracellular matrix proteins providing the aortic wall with adequate mechanical properties and resistance for proper function. Our study aimed at investigating the relationship between the elastin concentration of the wall of normal and aneurysmal abdominal aortas (AAA), the collagen concentration, and its extractibility, as a function of their size. Infrarenal aortas were collected from 30 patients undergoing operative repair of abdominal aortic aneurysm. Age-matched control samples were obtained from eight autopsies of individuals without vascular disease. Samples were divided into five groups according to the aortic diameter: control group (group N, n = 8); < 50 mm (group I, n = 6); between 50-75 mm (group II, n = 10); >75 mm (group III, n = 7); and ruptured (group IV, n = 7). The collagen concentration in samples from group I was similar to the controls. An increased collagen concentration was observed in group II and remained at the same level in the largest and ruptured aneurysms. Extractibility of collagen was found to be increased in group III and was even higher in group IV. A highly significant reduction in elastin concentration was observed in group I and there was progressive reduction with increasing diameter and rupture. A significant correlation could be established between aortic diameter, increased collagen extractibility and decreased elastin content. © 1993 Grune & Stratton Ltd.

引用

页码：633 / 637

页数：5

共 19 条

[1]

Sumner, Hokanson, Strandness, Stress-strain characteristics and collagen-elastin content of abdominal aortic aneurysms, Surg Gynecol Obstet, 130, pp. 459-466, (1970)

[2]

Campa, Greehalgh, Powell, Elastin degradation in abdominal aortic aneurysms, Atherosclerosis, 65, pp. 13-21, (1987)

[3]

Rizzo, McCarthy, Dixit, Lilly, Shively, Flinn, Yao, Collagen types and matrix protein content in human abdominal aortic aneurysms, J Vasc Surg, 10, pp. 365-373, (1989)

[4]

Dubick, Hunter, Perez-Lizano, Mar, Geokas, Assessment of the role of pancreatic proteases in human abdominal aortic aneurysms and occlusive disease, Clin Chim Acta, 177, pp. 1-10, (1988)

[5]

Menashi, Campa, Greenhalgh, Powell, Collagen in abdominal aortic aneurysm: Typing, content and degradation, J Vasc Surg, 6, pp. 578-582, (1987)

[6]

Busuttil, Rinderbreicht, Flesher, Carmacle, Elastase activity: The role of elastase in aortic aneurysm formation, Journal of Surgical Research, 32, pp. 214-217, (1983)

[7]

Cohen, Mandell, Chang, Wise, Elastin metabolism of the infrarenal aorta, J Vasc Surg, 7, pp. 210-214, (1988)

[8]

Brophy, Sumpio, Reilly, Tilson, Decreased tissue inhibitor of metalloproteinases (TIMP) in abdominal aortic aneurysm tissue: a preliminary report, Surg Res, 50, pp. 653-657, (1991)

[9]

Cohen, Sarfati, Ratner, Tilson, Alphal-antitrypsin phentotypes in patients with abdominal aortic aneurysms, J Vasc Res, 49, pp. 319-321, (1990)

[10]

Limet, Sakalihasan, Albert, Determination of the expansion rate and incidence of rupture of abdominal aortic aneurysms, J Vasc Surg, 14, pp. 540-548, (1991)

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