EARLY CHANGES IN CEREBRAL SODIUM DISTRIBUTION FOLLOWING ISCHEMIA MONITORED BY NA-23 MAGNETIC-RESONANCE-IMAGING

被引：5

作者：

ALLEN, KL

BUSZA, AL

WILLIAMS, SR

WILLIAMS, SCR

机构：

[1] Department of Neurochemistry, The Institute of Neurology, London

[2] The Royal College, Surgeons Unit of Biophysics, Institute of Child Health, London

[3] Queen Mary and Westfield College, London

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 06期

基金：

英国惠康基金;

关键词：

GERBIL; SODIUM; ISCHEMIA; REPERFUSION; MRI;

D O I：

10.1016/0730-725X(94)92030-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Na-23 magnetic resonance imaging has been used in this preliminary study to investigate early changes in brain sodium signal intensity during and after cerebral ischaemia in a gerbil model. The total sodium signal in selected brain regions decreased between 15 and 30% within 4 min of the onset of ischaemia, and then remained constant throughout the ischaemic period. The same pattern was observed in the eyes. On reperfusion, there was no significant change in the sodium signal over the first 4 min, but by 8 min the signal intensity had returned to or passed through control levels in all regions measured, with the exception of the eyes. These observations are consistent with the loss and resynthesis of ATP as seen in this model, and may be reflecting the redistribution of tissue sodium resulting from energy failure and recovery.

引用

页码：895 / 900

页数：6

共 12 条

[1]

Kohler, Kolodny, Sodium magnetic resonance imaging and chemical shift imaging, Prog. NMR Spectrosc., 24, pp. 411-433, (1992)

[2]

Perman, Turski, Houston, Glover, Hayes, Methodology of in vivo human sodium NMR imaging at 1.5 Tesla, Radiology, 160, pp. 811-820, (1986)

[3]

Eleff, Maruki, Monsein, Traystman, Bryan, Koehler, Sodium, ATP, and intracellular pH transients during reversible complete ischemia of dog cerebrum, Stroke, 22, pp. 233-241, (1991)

[4]

Naritomi, Sasaki, Kanashiro, Kitani, Sawada, Flow thresholds for cerebral energy disturbance and Na+ pump failure as studied by in vivo 31P and 23Na nuclear magnetic resonance spectroscopy, J. Cereb. Blood Flow Metab., 8, pp. 16-23, (1988)

[5]

Hilal, Maudsley, Simon, Perman, Bonn, Mawad, Silver, Ganti, Sane, Chien, In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke, AJNR, 4, (1983)

[6]

Moseley, Chew, Nishimura, Richards, Murphy-Boesch, Young, Marschner, Pitts, James, In vivo sodium-23 magnetic resonance surface coil imaging: Observing experimental cerebral ischemia in the rat, Magn. Reson. Imaging, 3, pp. 383-387, (1985)

[7]

Allen, Busza, Proctor, King, Williams, Crockard, Gadian, Controllable graded cerebral ischaemia in the gerbil: Studies of cerebral blood flow and energy metabolism by hydrogen clearance and 31P NMR spectroscopy, NMR Biomed., 6, pp. 181-186, (1993)

[8]

Kinchesh, Powlson, Randall, Williams, NMR imaging of 14N in solution, J. Magn. Reson., 97, pp. 208-212, (1992)

[9]

Crockard, Gadian, Frackowiak, Proctor, Allen, Williams, Ross Russell, Acute cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. II. Changes during ischaemia, J. Cereb. Blood Flow Metab., 7, pp. 394-402, (1987)

[10]

Allen, Busza, Crockard, Frackowiak, Gadian, Proctor, Ross Russell, Williams, Acute cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. III. Changes following ischaemia, J. Cereb. Blood Flow Metab., 8, pp. 816-821, (1988)

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