A SIMPLIFIED AND ECONOMICAL INTRADERMAL REGIMEN OF PURIFIED CHICK-EMBRYO CELL RABIES VACCINE FOR POSTEXPOSURE PROPHYLAXIS

被引:33
作者
SUNTHARASAMAI, P
CHAIPRASITHIKUL, P
WASI, C
SUPANARANOND, W
AUEWARAKUL, P
CHANTHAVANICH, P
SUPAPOCHANA, A
AREERAKSA, S
CHITTAMAS, S
JITTAPALAPONGSA, S
PITTISUTHITHAM, P
THONGCHAROEN, P
机构
[1] MAHIDOL UNIV,FAC TROP MED,DEPT TROP PEDIAT,BANGKOK 10400,THAILAND
[2] MAHIDOL UNIV,SIRIRAJ HOSP,FAC MED,DEPT MICROBIOL,BANGKOK 10700,THAILAND
[3] KASETSART UNIV,FAC VET MED,BANGKOK,THAILAND
关键词
PCEC RABIES VACCINE; RABIES POSTEXPOSURE PROPHYLAXIS; INTRADERMAL ADMINISTRATION OF VACCINE;
D O I
10.1016/0264-410X(94)90308-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Healthy volunteers were randomized to receive either intradermal purified chick embryo cell rabies vaccine (PCEC) alone (0.1 ml at each of two sites on days 0, 3 and 7, and at one site on days 28 and 90) (n=81), or intradermal PCEC with one dose of human rabies immunoglobulin (HRIG) intramuscularly at 20 IU kg(-1) on day 0 (n=52). Neutralizing antibody (NAB) was detectable in every volunteer, in both groups, from day 14 up to day 365. The peak NAB occurred on day 28 in both groups. No significant suppressive effects of HRIG on NAB response were observed. Side-effects were mild and self-limiting. These preliminary results suggest that this simplified low-dose intradermal regimen could be an alternative schedule in rabies postexposure prophylaxis, resulting in lower overall costs.
引用
收藏
页码:508 / 512
页数:5
相关论文
共 36 条
  • [1] BARTH R, 1983, LANCET, V1, P700
  • [2] A NEW INACTIVATED TISSUE-CULTURE RABIES VACCINE FOR USE IN MAN EVALUATION OF PCEC-VACCINE BY LABORATORY TESTS
    BARTH, R
    GRUSCHKAU, H
    BIJOK, U
    HILFENHAUS, J
    HINZ, J
    MILCKE, L
    MOSER, H
    JAEGER, O
    RONNEBERGER, H
    WEINMANN, E
    [J]. JOURNAL OF BIOLOGICAL STANDARDIZATION, 1984, 12 (01): : 29 - &
  • [3] BOEGEL K, 1986, B WORLD HEALTH ORGAN, V66, P883
  • [4] Chutivongse S, 1988, Asia Pac J Public Health, V2, P179
  • [5] POSTEXPOSURE PROPHYLAXIS FOR RABIES WITH ANTISERUM AND INTRADERMAL VACCINATION
    CHUTIVONGSE, S
    WILDE, H
    SUPICH, C
    BAER, GM
    FISHBEIN, DB
    [J]. LANCET, 1990, 335 (8694) : 896 - 898
  • [6] CHUTIVONGSE S, 1989, VACCINE, V7, P6546
  • [7] GARDNER MJ, 1989, STATISTICS CONFIDENC, P119
  • [8] HARVERSON G, 1984, LANCET, V2, P313
  • [9] INGELFINGER JA, 1983, BIOSTATISTICS CLIN M, P129
  • [10] Ljubicic M, 1985, IMPROVEMENTS RABIES, P95