ABERRATIONS OF CHROMOSOME-22 AND POLYSOMY OF CHROMOSOME-8 AS NONRANDOM CHANGES IN CLEAR-CELL SARCOMA

被引：20

作者：

LIMON, J ^{[1
]}

DEBIECRYCHTER, M ^{[1
]}

NEDOSZYTKO, B ^{[1
]}

LIBERSKI, PP ^{[1
]}

BABINSKA, M ^{[1
]}

SZADOWSKA, A ^{[1
]}

机构：

[1] MED ACAD LODZ,DEPT ONCOL,LODZ,POLAND

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 72卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)90130-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis was performed on a primary tumor and a metastatic lesion of a clear cell sarcoma of tendons and aponeuroses (CCS), a rare soft tissue neoplasm of uncertain histopathologic origin. Clonal chromosomal abnormalities resulting in two related clones were found in both tumors. The karyotype was near-triploid with several structural and numerical changes, comprising a der(15;22)(q10;q10). Including the present case, 14 of 15 cases of CCS have had structural or numerical aberrations of chromosome 22 and nine of them (65%) displayed a similar or identical t(12;22)(q13-14;q12-13). Our findings suggest that in the absence of specific t(12;22), other abnormalities of chromosome 22 may be significant. In addition, increased doses of chromosome 8 found in 70% of the tumors strongly suggest a significant role for this chromosome in the development of clear cell sarcoma.

引用

页码：141 / 145

页数：5

共 22 条

[1] NEUROBLASTIC DIFFERENTIATION OF METASTASES OF MEDULLOBLASTOMA TO EXTRACRANIAL LYMPH-NODE - AN ULTRASTRUCTURAL-STUDY [J].