CHARACTERIZATION OF PRODUCTS OF ALKYLATION OF 2'-DEOXYADENOSINE AND 2'-DEOXYGUANOSINE BY CHLOROETHYL ETHYL SULFIDE

被引：9

作者：

SACK, GH

FENSELAU, C

KAN, MNN

KAN, LS

WOOD, GW

LAU, PY

机构：

[1] JOHNS HOPKINS MED INST, BALTIMORE, MD 21205 USA

[2] UNIV WINDSOR, DEPT CHEM, WINDSOR N9B 3P4, ONTARIO, CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1978年 / 43卷 / 20期

关键词：

D O I：

10.1021/jo00414a028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of 2'-deoxyadenosine by 2-chloroethyl ethyl sulfide (CEES) in aqueous solutions at pH 6.0 and 25°C led to two products. These have been isolated and characterized on the basis of mass spectrometry, nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy as 2'-deoxy-1-[2-(ethylthio)ethyl]adenosine and 2'-deoxy-N6-[2-(ethylthio)ethyl]adenosine. The products formed from 2'-deoxyguanosine under these same conditions were identified as 2'-deoxy-7-[2-(ethylthio)ethyl]guanosine and 2'-deoxy-N2-[2-(ethylthio)ethyl]guanosine, the corresponding pair of deribosylated alkylated purines. © 1978, American Chemical Society. All rights reserved.

引用

页码：3932 / 3936

页数：5

共 34 条

[1] CHEMICAL PRODUCTION OF MUTATIONS [J].