STUDIES ON THE EFFECT OF ASCORBIC-ACID AND SELENIUM ON THE GENOTOXICITY OF NITROFURANS - NITROFURAZONE AND FURAZOLIDONE

被引：30

作者：

GAJEWSKA, J ^{[1
]}

SZCZYPKA, M ^{[1
]}

TUDEK, B ^{[1
]}

SZYMCZYK, T ^{[1
]}

机构：

[1] MED ACAD WARSAW,INST BIOPHARM,DEPT BIOCHEM,WARSAW,POLAND

来源：

MUTATION RESEARCH | 1990年 / 232卷 / 02期

关键词：

Ames test; Antioxidants; Ascorbic acid; Furazolidone; Genotoxic activity; Nitrofurazone; Sodium selenite; SOS-chromotest;

D O I：

10.1016/0027-5107(90)90124-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxic properties of nitrofurazone and furazolidone were studied using the Ames test and SOS-chromotest. Both compounds were found to act as strong mutagens on the TA97 and TA102 strains of S. typhimurium and to induce the SOS-repair system in the PQ37 strain of E. coli. A good concordance was found between the mutagenic activity and the ability to induce the SOS system. Ascorbic acid and sodium selenite only very slightly lowered the genotoxic effect of the 2 nitrofurans studied both in the Ames test and in the SOS-chromotest. © 1990.

引用

页码：191 / 197

页数：7

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